Model Unravels Rules That Govern How Genes Are Switched On And Off

January 14, 2009

For years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell.

Now, scientists at Washington University School of Medicine in St. Louis report they have developed a model of gene expression in yeast that predicts with a high degree of accuracy whether a gene will be switched on or off. The study is now available in the advance online publication of Read the rest of this entry »

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